HOT-x (psychedelics)

HOT-x, also known as 2,5-dimethoxy-4-(β-alkylthio)-N-hydroxyphenethylamines, are a group of psychedelic drugs of the phenethylamine and 2C families. They have a hydroxy group (HO) at the amine as well as methoxy groups at the 2 and 5 positions and an alkylthio (T) group at the 4 position of the phenyl ring. The HOT-x drugs are the N-hydroxyl analogues of the corresponding 2C-T-x drugs. They were synthesized and tested by Alexander Shulgin and reported in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).

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