HOXA7

HOXA7
Identifiers
Aliases	HOXA7, ANTP, HOX1, HOX1.1, HOX1A, homeobox A7
External IDs	OMIM: 142950; MGI: 96179; HomoloGene: 56001; GeneCards: HOXA7; OMA:HOXA7 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	27,157,936 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	52,198,834 bp
RNA expression pattern
	Top expressed in
	oocyte; ; mucosa of transverse colon; ; secondary oocyte; ; sperm; ; biceps brachii; ; tendon of biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; gonad; ; right adrenal gland; ; right adrenal cortex;
	Top expressed in
	tail of embryo; ; zygote; ; right kidney; ; secondary oocyte; ; thoracic vertebral column; ; proximal tubule; ; muscle of thigh; ; embryo; ; neural tube; ; efferent ductule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;
Cellular component	nucleus; nucleoplasm; nuclear membrane;
Biological process	embryonic skeletal system morphogenesis; negative regulation of monocyte differentiation; negative regulation of keratinocyte differentiation; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; stem cell differentiation; transcription, DNA-templated; negative regulation of cell-matrix adhesion; multicellular organism development; angiogenesis; negative regulation of transcription, DNA-templated; negative regulation of leukocyte migration; anterior/posterior pattern specification; positive regulation of transcription by RNA polymerase II; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	3204
	15404
	ENSG00000122592
	ENSMUSG00000038236
	P31268
	P02830
	NM_006896
	NM_010455
	NP_008827
	NP_034585
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.