HOXA9

HOXA9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PUF
Identifiers
Aliases	HOXA9, ABD-B, HOX1, HOX1.7, HOX1G, homeobox A9
External IDs	OMIM: 142956; MGI: 96180; HomoloGene: 7766; GeneCards: HOXA9; OMA:HOXA9 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	27,175,180 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	52,208,069 bp
RNA expression pattern
	Top expressed in
	testicle; ; glomerulus; ; metanephric glomerulus; ; biceps brachii; ; kidney tubule; ; Skeletal muscle tissue of biceps brachii; ; human penis; ; tibia; ; vulva; ; skin of hip;
	Top expressed in
	renal corpuscle; ; tail of embryo; ; motor neuron; ; transitional epithelium of urinary bladder; ; gastrula; ; medullary collecting duct; ; vas deferens; ; abdominal wall; ; decidua; ; foot;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; protein binding; enzyme binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	nucleus; transcription regulator complex; cytoplasm;
Biological process	regulation of transcription, DNA-templated; endothelial cell activation; transcription, DNA-templated; multicellular organism development; regulation of transcription by RNA polymerase II; negative regulation of myeloid cell differentiation; spermatogenesis; single fertilization; male gonad development; anterior/posterior pattern specification; proximal/distal pattern formation; regulation of gene expression; mammary gland development; embryonic forelimb morphogenesis; positive regulation of transcription by RNA polymerase II; embryonic skeletal system development; uterus development; definitive hemopoiesis;
	Sources:Amigo / QuickGO
Orthologs
	3205
	15405
	ENSG00000078399
	ENSMUSG00000038227
	P31269
	P09631
	NM_152739; NM_002142
	NM_001277238; NM_010456
	NP_689952
	NP_001264167; NP_034586
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene.

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila fly. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis.

As HOXA9 dysfunction has been implicated in acute myeloid leukemia, and expression of the gene has been shown to differ markedly between erythrocyte lineages of different stages of development, the gene is of particular interest from a hematopoietic perspective.