HOXC11

HOXC11
Identifiers
Aliases	HOXC11, HOX3H, homeobox C11
External IDs	OMIM: 605559; MGI: 96193; HomoloGene: 130362; GeneCards: HOXC11; OMA:HOXC11 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,977,643 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,866,143 bp
RNA expression pattern
	Top expressed in
	testicle; ; skin of leg; ; popliteal artery; ; tibial arteries; ; skin of abdomen; ; saphenous vein; ; lower limb muscles; ; muscle of leg; ; gastrocnemius muscle; ; subcutaneous adipose tissue;
	Top expressed in
	tail of embryo; ; paramesonephric duct; ; male urethra; ; muscle tissue; ; skeletal muscle tissue; ; muscle of thigh; ; genital tubercle; ; quadriceps femoris muscle; ; embryo; ; mesonephric duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; cytosol;
Biological process	multicellular organism development; embryonic skeletal joint morphogenesis; skeletal system development; proximal/distal pattern formation; embryonic digit morphogenesis; endoderm development; metanephros development; regulation of transcription, DNA-templated; organ induction; anterior/posterior pattern specification; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	3227
	109663
	ENSG00000123388
	ENSMUSG00000001656
	O43248
	P31313
	NM_014212
	NM_001024842
	NP_055027
	NP_001020013
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.

Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined.