Hippocalcin

HPCA
Identifiers
Aliases	HPCA, BDR2, DYT2, hippocalcin
External IDs	OMIM: 142622; MGI: 1336200; HomoloGene: 55634; GeneCards: HPCA; OMA:HPCA - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	32,898,441 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	129,015,829 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; middle frontal gyrus; ; putamen; ; nucleus accumbens; ; external globus pallidus; ; prefrontal cortex; ; right frontal lobe; ; Region I of hippocampus proper; ; Brodmann area 10; ; dorsolateral prefrontal cortex;
	Top expressed in
	CA3 field; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; olfactory tubercle; ; primary visual cortex; ; hippocampus proper; ; Region I of hippocampus proper; ; nucleus accumbens; ; perirhinal cortex; ; globus pallidus;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; actin binding; calcium ion binding; identical protein binding; kinase binding;
Cellular component	perikaryon; dendrite membrane; neuronal cell body membrane; axon; dendritic spine head; dendrite cytoplasm; cytosol; extrinsic component of membrane; cytoplasm; membrane; postsynapse; glutamatergic synapse;
Biological process	positive regulation of adenylate cyclase activity; response to organic cyclic compound; cellular response to monosodium glutamate; negative regulation of guanylate cyclase activity; positive regulation of phospholipase activity; activation of phospholipase D activity; brain development; retina development in camera-type eye; response to ketamine; response to L-glutamate; inner ear development; response to Aroclor 1254; calcium-mediated signaling; positive regulation of protein targeting to membrane; cellular response to electrical stimulus; cellular response to calcium ion; regulation of voltage-gated calcium channel activity; regulation of postsynaptic neurotransmitter receptor internalization;
	Sources:Amigo / QuickGO
Orthologs
	3208
	15444
	ENSG00000121905
	ENSMUSG00000028785
	P84074
	P84075
	NM_002143
	NM_001130419; NM_010471; NM_001286081; NM_001286083
	NP_002134
	NP_001123891; NP_001273010; NP_001273012; NP_034601
	Wikidata
View/Edit Human	View/Edit Mouse

Hippocalcin is a protein that in humans is encoded by the HPCA gene.

Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins. It is expressed in mammalian brains especially in the hippocampus. It possesses a Ca²⁺/myristoyl switch.