HPGD

HPGD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GDZ
Identifiers
Aliases	HPGD, 15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1, hydroxyprostaglandin dehydrogenase 15-(NAD), 15-hydroxyprostaglandin dehydrogenase
External IDs	OMIM: 601688; MGI: 108085; HomoloGene: 68095; GeneCards: HPGD; OMA:HPGD - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	174,523,154 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	56,774,078 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; rectum; ; mucosa of colon; ; placenta; ; metanephric glomerulus; ; right lung; ; lower lobe of lung; ; mucosa of sigmoid colon; ; mucosa of transverse colon; ; mucosa of ileum;
	Top expressed in
	right lung lobe; ; seminal vesicula; ; wall of urinary bladder; ; mucosa of urinary bladder; ; transitional epithelium of urinary bladder; ; pyloric antrum; ; epithelium of stomach; ; left colon; ; body of femur; ; duodenum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	NAD binding; 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; catalytic activity; prostaglandin E receptor activity; NAD+ binding; oxidoreductase activity; protein homodimerization activity;
Cellular component	nucleoplasm; basolateral plasma membrane; extracellular exosome; cytoplasm; cytosol; extracellular space;
Biological process	prostaglandin metabolic process; thrombin-activated receptor signaling pathway; lipid metabolism; negative regulation of cell cycle; fatty acid metabolic process; lipoxygenase pathway; birth; lipoxin metabolic process; transforming growth factor beta receptor signaling pathway; ovulation; ductus arteriosus closure; response to lipopolysaccharide; kidney development; female pregnancy; response to estradiol; positive regulation of apoptotic process; response to ethanol; positive regulation of vascular associated smooth muscle cell proliferation; long-chain fatty acid biosynthetic process; lipoxin biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	3248
	15446
	ENSG00000164120
	ENSMUSG00000031613
	P15428
	Q8VCC1
NM_000860; NM_001145816; NM_001256301; NM_001256305; NM_001256306;
	NM_001256307; NM_001363574
	NM_008278
NP_000851; NP_001139288; NP_001243230; NP_001243234; NP_001243235;
	NP_001243236; NP_001350503
	NP_032304
	Wikidata
View/Edit Human	View/Edit Mouse

Hydroxyprostaglandin dehydrogenase 15-(NAD) (the HUGO-approved official symbol = HPGD; HGNC ID, HGNC:5154), also called 15-hydroxyprostaglandin dehydrogenase [NAD+], is an enzyme that in humans is encoded by the HPGD gene.

In melanocytic cells HPGD gene expression may be regulated by MITF.