HPN (gene)

HPN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1O5E, 1O5F, 1P57, 1Z8G, 3T2N, 5CE1
Identifiers
Aliases	HPN, TMPRSS1, hepsin
External IDs	OMIM: 142440; MGI: 1196620; HomoloGene: 20498; GeneCards: HPN; OMA:HPN - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,066,573 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,814,715 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; body of pancreas; ; kidney tubule; ; body of stomach; ; gastrocnemius muscle; ; left lobe of thyroid gland; ; human kidney; ; muscle of thigh; ; right lobe of thyroid gland; ; pancreatic ductal cell;
	Top expressed in
	right kidney; ; left lobe of liver; ; proximal tubule; ; human kidney; ; yolk sac; ; renal pelvis; ; medullary collecting duct; ; blastocyst; ; vestibular sensory epithelium; ; epithelium of stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	serine-type exopeptidase activity; calcium-activated potassium channel activity; peptidase activity; protein binding; serine-type peptidase activity; hydrolase activity; serine-type endopeptidase activity;
Cellular component	integral component of membrane; nuclear membrane; endoplasmic reticulum membrane; membrane; cell-cell junction; integral component of plasma membrane; cell surface; soma; apical plasma membrane; extracellular exosome; plasma membrane;
Biological process	positive regulation of hepatocyte proliferation; positive regulation of plasminogen activation; response to thyroid hormone; negative regulation of apoptotic process; proteolysis; detection of mechanical stimulus involved in sensory perception of sound; positive regulation of thyroid hormone generation; positive regulation of cell growth; positive regulation of gene expression; pilomotor reflex; cochlea morphogenesis; potassium ion transmembrane transport; regulation of cell shape; negative regulation of epithelial cell proliferation; basement membrane disassembly; negative regulation of epithelial to mesenchymal transition; hepatocyte growth factor receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3249
	15451
	ENSG00000105707
	ENSMUSG00000001249
	P05981
	O35453
	NM_002151; NM_182983; NM_001375441; NM_001384133
	NM_001110252; NM_001276269; NM_008281
	NP_002142; NP_892028; NP_001362370; NP_001371062
	NP_001103722; NP_001263198; NP_032307
	Wikidata
View/Edit Human	View/Edit Mouse

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Hepsin-SRCR
Hepsin-SRCR
	extracellular domain of human hepsin
Identifiers
Symbol	Hepsin-SRCR
Pfam	PF09272
InterPro	IPR015352
SCOP2	1p57 / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Serine protease hepsin is an enzyme that in humans is encoded by the HPN gene.