Heparanase

HPSE
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5E97, 5E9B, 5E8M, 5E98, 5E9C
Identifiers
Aliases	HPSE, HPA, HPA1, HPR1, HPSE1, HSE1, heparanase
External IDs	OMIM: 604724; MGI: 1343124; HomoloGene: 68528; GeneCards: HPSE; OMA:HPSE - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	83,335,153 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	100,867,582 bp
RNA expression pattern
	Top expressed in
	monocyte; ; gums; ; gingival epithelium; ; blood; ; human penis; ; oral cavity; ; granulocyte; ; germinal epithelium; ; gonad; ; minor salivary glands;
	Top expressed in
	iris; ; stria vascularis; ; mesenteric lymph nodes; ; blood; ; calvaria; ; lumbar spinal ganglion; ; stroma of bone marrow; ; esophagus; ; otolith organ; ; set of bones of free part of upper limb;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein dimerization activity; heparanase activity; beta-glucuronidase activity; hydrolase activity, acting on glycosyl bonds; protein binding; syndecan binding; hydrolase activity;
Cellular component	intracellular membrane-bounded organelle; membrane; nucleoplasm; lysosomal membrane; lysosomal lumen; membrane raft; lysosome; nucleus; extracellular region; specific granule lumen; extracellular matrix;
Biological process	positive regulation of osteoblast proliferation; positive regulation of protein kinase B signaling; heparan sulfate proteoglycan catabolic process; regulation of hair follicle development; positive regulation of hair follicle development; wound healing; vascular wound healing; cell adhesion; positive regulation of blood coagulation; proteoglycan metabolic process; glycosaminoglycan catabolic process; positive regulation of vascular endothelial growth factor production; cell-matrix adhesion; angiogenesis involved in wound healing; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	10855
	15442
	ENSG00000173083
	ENSMUSG00000035273
	Q9Y251
	Q6YGZ1
	NM_006665; NM_001098540; NM_001166498; NM_001199830
	NM_152803
	NP_001092010; NP_001159970; NP_001186759; NP_006656
	NP_690016
	Wikidata
View/Edit Human	View/Edit Mouse

Heparanase, also known as HPSE, is an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate molecules into shorter chain length oligosaccharides.