HS3ST2

HS3ST2
Identifiers
Aliases	HS3ST2, 30ST2, 3OST2, heparan sulfate-glucosamine 3-sulfotransferase 2
External IDs	OMIM: 604056; MGI: 1333802; HomoloGene: 21220; GeneCards: HS3ST2; OMA:HS3ST2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	22,916,338 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	121,100,993 bp
RNA expression pattern
	Top expressed in
	Brodmann area 46; ; orbitofrontal cortex; ; Region I of hippocampus proper; ; postcentral gyrus; ; superior frontal gyrus; ; dorsolateral prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; endothelial cell; ; Brodmann area 9;
	Top expressed in
	lumbar spinal ganglion; ; prefrontal cortex; ; primary motor cortex; ; lateral septal nucleus; ; superior frontal gyrus; ; visual cortex; ; molecular layer of cerebellar cortex; ; primary visual cortex; ; pineal gland; ; granular layer;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; [heparan sulfate-glucosamine 3-sulfotransferase 2 activity]; [heparan sulfate-glucosamine 3-sulfotransferase 1 activity]; heparan sulfate sulfotransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane;
Biological process	circadian rhythm; glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9956
	195646
	ENSG00000122254
	ENSMUSG00000046321
	Q9Y278
	Q673U1
	NM_006043
	NM_001081327; NM_177575
	NP_006034
	NP_001074796
	Wikidata
View/Edit Human	View/Edit Mouse

Heparan sulfate glucosamine 3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the HS3ST2 gene.

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system.

Role in breast cancer The HS3ST2 promoter is hypermethylated in breast cancer tissue compared to normal breast ducts, suggesting a potential involvement in the pathogenesis of the disease. Functional analysis revealed that upregulation of HS3ST2 in human breast cancer cells resulted in altered invasiveness, which was due to changes in Mitogen-activated protein kinase signaling and matrix metalloproteinase expression.