HS3ST3A1

HS3ST3A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1T8T, 1T8U
Identifiers
Aliases	HS3ST3A1, 30ST3A1, 3OST3A1, 3-OST-3A, heparan sulfate-glucosamine 3-sulfotransferase 3A1
External IDs	OMIM: 604057; MGI: 1333861; HomoloGene: 88735; GeneCards: HS3ST3A1; OMA:HS3ST3A1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	13,601,929 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	64,413,667 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; testicle; ; tibia; ; gingival epithelium; ; oral cavity; ; glomerulus; ; metanephric glomerulus; ; seminal vesicula; ; stromal cell of endometrium; ; germinal epithelium;
	Top expressed in
	metatarsal bones; ; condyle; ; second metatarsal bone; ; fifth metatarsal bone; ; iris; ; footplate; ; Gonadal ridge; ; third metatarsal bone; ; ciliary body; ; renal corpuscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; [heparan sulfate-glucosamine 3-sulfotransferase 3 activity]; [heparan sulfate-glucosamine 3-sulfotransferase 1 activity]; heparan sulfate sulfotransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane;
Biological process	glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9955
	15478
	ENSG00000153976
	ENSMUSG00000047759
	Q9Y663
	Q8BKN6
	NM_006042
	NM_178870
	NP_006033
	NP_849201
	Wikidata
View/Edit Human	View/Edit Mouse

Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 is an enzyme that in humans is encoded by the HS3ST3A1 gene.

Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family.

It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in the liver and placenta.