HSD17B10

HSD17B10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SO8, 1U7T, 2O23
Identifiers
Aliases	HSD17B10, 17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1, hydroxysteroid (17-beta) dehydrogenase 10, hydroxysteroid 17-beta dehydrogenase 10, HSD10MD
External IDs	OMIM: 300256; MGI: 1333871; HomoloGene: 68403; GeneCards: HSD17B10; OMA:HSD17B10 - orthologs
EC number	1.1.1.51
Gene location (Human)
Chr.	X chromosome (human)
End	53,434,370 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	150,787,438 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; apex of heart; ; human kidney; ; mucosa of esophagus; ; right auricle of heart; ; left ventricle;
	Top expressed in
	left lobe of liver; ; epithelium of lens; ; cumulus cell; ; vestibular sensory epithelium; ; right kidney; ; right ventricle; ; epithelium of stomach; ; medullary collecting duct; ; brown adipose tissue; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	testosterone dehydrogenase [NAD(P) activity]; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity; protein binding; oxidoreductase activity; cholate 7-alpha-dehydrogenase activity; RNA binding; 3-hydroxyacyl-CoA dehydrogenase activity; tRNA binding; dihydrotestosterone 17-beta-dehydrogenase activity;
Cellular component	cytoplasm; plasma membrane; mitochondrial matrix; mitochondrion; mitochondrial ribonuclease P complex;
Biological process	lipid metabolism; branched-chain amino acid catabolic process; mitochondrial tRNA processing; mitochondrial tRNA methylation; tRNA processing; mitochondrion organization; protein homotetramerization; mitochondrial tRNA 5'-end processing; mitochondrial tRNA 3'-end processing;
	Sources:Amigo / QuickGO
Orthologs
	3028
	15108
	ENSG00000072506
	ENSMUSG00000025260
	Q99714
	O08756
	NM_004493; NM_001037811
	NM_016763
	NP_001032900; NP_004484
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

17-β-Hydroxysteroid dehydrogenase X (HSD10) also known as 3-hydroxyacyl-CoA dehydrogenase type-2 is a mitochondrial enzyme that in humans is encoded by the HSD17B10 (hydroxysteroid (17β) dehydrogenase 10) gene. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. Human HSD10 cDNA was cloned from the brain (NM_004493), and the resulting protein, a homotetramer, was first characterized as a short chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD). Active sites of this enzyme can accommodate different substrates; 17β-HSD10 is involved in the oxidation of isoleucine, branched-chain fatty acids, and xenobiotics as well as the metabolism of sex hormones and neuroactive steroids.