HSD17B12

HSD17B12
Identifiers
Aliases	HSD17B12, KAR, SDR12C1, hydroxysteroid (17-beta) dehydrogenase 12, hydroxysteroid 17-beta dehydrogenase 12
External IDs	OMIM: 609574; MGI: 1926967; HomoloGene: 95094; GeneCards: HSD17B12; OMA:HSD17B12 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	43,856,617 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	93,988,309 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; retinal pigment epithelium; ; pancreatic ductal cell; ; optic nerve; ; pars reticulata; ; inferior ganglion of vagus nerve; ; cardia; ; renal medulla; ; spinal ganglia; ; pars compacta;
	Top expressed in
	skin of external ear; ; brown adipose tissue; ; transitional epithelium of urinary bladder; ; cumulus cell; ; tunica adventitia of aorta; ; left lobe of liver; ; ciliary body; ; iris; ; sciatic nerve; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparin binding; estradiol 17-beta-dehydrogenase activity; oxidoreductase activity; collagen binding; fibronectin binding; protein binding; 3-oxo-lignoceroyl-CoA reductase activity; 3-oxo-behenoyl-CoA reductase activity; long-chain-3-hydroxyacyl-CoA dehydrogenase activity; 3-oxo-arachidoyl-CoA reductase activity; 3-oxo-cerotoyl-CoA reductase activity;
Cellular component	integral component of membrane; membrane; endoplasmic reticulum; endoplasmic reticulum membrane; extracellular matrix;
Biological process	lipid metabolism; extracellular matrix organization; long-chain fatty-acyl-CoA biosynthetic process; positive regulation of cell-substrate adhesion; fatty acid biosynthetic process; estrogen biosynthetic process; steroid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	51144
	56348
	ENSG00000149084
	ENSMUSG00000027195
	Q53GQ0
	O70503
	NM_016142
	NM_019657
	NP_057226
	NP_062631
	Wikidata
View/Edit Human	View/Edit Mouse

Estradiol 17-beta-dehydrogenase 12 is an enzyme that in humans is encoded by the HSD17B12 gene.

The enzyme 17-beta hydroxysteroid dehydrogenase-12 (HSD17B12) uses NADPH to reduce 3-ketoacyl-CoA to 3-hydroxyacyl-CoA during the second step of fatty acid elongation.[supplied by OMIM]