HSD17B13

HSD17B13
Identifiers
Aliases	HSD17B13, NIIL497, SCDR9, SDR16C3, HMFN0376, hydroxysteroid (17-beta) dehydrogenase 13, hydroxysteroid 17-beta dehydrogenase 13
External IDs	OMIM: 612127; MGI: 2140804; HomoloGene: 71549; GeneCards: HSD17B13; OMA:HSD17B13 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	87,322,886 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	104,125,276 bp
RNA expression pattern
	Top expressed in
	liver; ; right lobe of liver; ; olfactory zone of nasal mucosa; ; vagina; ; subcutaneous adipose tissue; ; lactiferous gland; ; myometrium; ; ectocervix; ; skin of leg; ; body of uterus;
	Top expressed in
	left lobe of liver; ; epithelium of small intestine; ; duodenum; ; zygote; ; secondary oocyte; ; ileum; ; migratory enteric neural crest cell; ; primary oocyte; ; islet of Langerhans; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; molecular function; steroid dehydrogenase activity;
Cellular component	extracellular region; lipid droplet; cytosol; cellular component;
Biological process	positive regulation of lipid biosynthetic process; lipid droplet organization; biological process;
	Sources:Amigo / QuickGO
Orthologs
	345275
	243168
	ENSG00000170509
	ENSMUSG00000034528
	Q7Z5P4
	Q8VCR2
	NM_178135; NM_001136230
	NM_001163486; NM_198030
	NP_001129702; NP_835236
	NP_001156958; NP_932147
	Wikidata
View/Edit Human	View/Edit Mouse

17β-Hydroxysteroid dehydrogenase type 13 also known as 17β-HSD type 13 is an enzyme that in humans is encoded by the HSD17B13 gene.

17β-HSD13 is significantly up-regulated in the liver of patients with non-alcoholic fatty liver disease (NAFLD) and enhances lipogenesis.