HSD17B14

HSD17B14
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1YDE, 5ICS, 5ICM, 5JS6, 5HS6, 5JSF
Identifiers
Aliases	HSD17B14, DHRS10, SDR47C1, retSDR3, hydroxysteroid (17-beta) dehydrogenase 14, hydroxysteroid 17-beta dehydrogenase 14
External IDs	OMIM: 612832; MGI: 1913315; HomoloGene: 133800; GeneCards: HSD17B14; OMA:HSD17B14 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,836,510 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,217,176 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; right adrenal cortex; ; right lobe of liver; ; left ovary; ; left adrenal cortex; ; nucleus accumbens; ; testicle; ; right ovary; ; right hemisphere of cerebellum; ; caudate nucleus;
	Top expressed in
	morula; ; blastocyst; ; lip; ; transitional epithelium of urinary bladder; ; embryo; ; muscle of thigh; ; esophagus; ; gastrula; ; blood; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; protein binding; testosterone 17-beta-dehydrogenase (NADP+) activity; identical protein binding; estradiol 17-beta-dehydrogenase activity;
Cellular component	cytoplasm; cytosol;
Biological process	steroid metabolic process; steroid catabolic process; lipid metabolism; estrogen biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	51171
	66065
	ENSG00000087076
	ENSMUSG00000030825
	Q9BPX1
	n/a
	NM_016246
	NM_025330
	NP_057330
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

17β-Hydroxysteroid dehydrogenase type 14 also known as 17β-HSD type 14 or 17βHSD14 is an enzyme that in humans is encoded by the HSD17B14 gene.

17βHSD14 catalyzes the stereospecific oxidation and reduction of the 17β carbon atom of androgens and estrogens using NAD(P)(H) as a cofactor. It is primarily expressed in glandular epithelial tissues of breast, ovary, and testis.