HSD17B4

HSD17B4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IKT, 1S9C, 1ZBQ
Identifiers
Aliases	HSD17B4, DBP, MFE-2, MPF-2, PRLTS1, SDR8C1, hydroxysteroid (17-beta) dehydrogenase 4, hydroxysteroid 17-beta dehydrogenase 4
External IDs	OMIM: 601860; MGI: 105089; HomoloGene: 358; GeneCards: HSD17B4; OMA:HSD17B4 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	119,637,199 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	50,329,336 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; right lobe of liver; ; left lobe of thyroid gland; ; corpus callosum; ; internal globus pallidus; ; right adrenal cortex; ; C1 segment; ; body of pancreas; ; left adrenal gland; ; left adrenal cortex;
	Top expressed in
	saccule; ; left lobe of liver; ; ectoderm; ; otic vesicle; ; otic placode; ; brown adipose tissue; ; external carotid artery; ; intercostal muscle; ; lacrimal gland; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; isomerase activity; lyase activity; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity; oxidoreductase activity; long-chain-enoyl-CoA hydratase activity; signaling receptor binding; 17-beta-hydroxysteroid dehydrogenase (NAD+) activity; 3-hydroxyacyl-CoA dehydrogenase activity;
Cellular component	membrane; peroxisome; peroxisomal membrane; peroxisomal matrix; mitochondrion; cytosol;
Biological process	estrogen metabolic process; androgen metabolic process; lipid metabolism; alpha-linolenic acid metabolic process; very long-chain fatty acid metabolic process; Sertoli cell development; fatty acid metabolic process; very long-chain fatty-acyl-CoA metabolic process; fatty acid beta-oxidation using acyl-CoA oxidase; osteoblast differentiation; medium-chain fatty-acyl-CoA metabolic process; fatty acid beta-oxidation; bile acid biosynthetic process; protein targeting to peroxisome;
	Sources:Amigo / QuickGO
Orthologs
	3295
	15488
	ENSG00000133835
	ENSMUSG00000024507
	P51659
	P51660
	NM_001292028; NM_000414; NM_001199291; NM_001199292; NM_001292027
	NM_008292
NP_000405; NP_001186220; NP_001186221; NP_001278956; NP_001278957;
	NP_001361426; NP_001361427; NP_001361428; NP_001361429; NP_001361430; NP_001361431; NP_001361432
	NP_032318
	Wikidata
View/Edit Human	View/Edit Mouse

D-bifunctional protein (DBP), also known as peroxisomal multifunctional enzyme type 2 (MFP-2), as well as 17β-hydroxysteroid dehydrogenase type IV (17β-HSD type IV) is a protein that in humans is encoded by the HSD17B4 gene. It's an alcohol oxidoreductase, specifically 17β-Hydroxysteroid dehydrogenase. It is involved in fatty acid β-oxidation and steroid metabolism (cf. steroidogenesis).