HSD17B7

HSD17B7
Identifiers
Aliases	HSD17B7, PRAP, SDR37C1, hydroxysteroid (17-beta) dehydrogenase 7, hydroxysteroid 17-beta dehydrogenase 7
External IDs	OMIM: 606756; MGI: 1330808; HomoloGene: 40728; GeneCards: HSD17B7; OMA:HSD17B7 - orthologs
EC number	1.1.1.62
Gene location (Human)
Chr.	Chromosome 1 (human)
End	162,812,823 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	169,796,810 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; anterior pituitary; ; C1 segment; ; upper lobe of left lung; ; islet of Langerhans; ; ectocervix;
	Top expressed in
	vestibular sensory epithelium; ; skin of external ear; ; Paneth cell; ; ciliary body; ; facial motor nucleus; ; condyle; ; hair follicle; ; substantia nigra; ; iris; ; medullary collecting duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; estradiol 17-beta-dehydrogenase activity; 3-keto sterol reductase activity;
Cellular component	integral component of membrane; plasma membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	estrogen biosynthetic process; cholesterol biosynthetic process; lipid metabolism; steroid biosynthetic process; nervous system development; cell differentiation; embryonic skeletal system development;
	Sources:Amigo / QuickGO
Orthologs
	51478
	15490
	ENSG00000132196
	ENSMUSG00000026675
	P56937
	O88736
	NM_001304512; NM_001304513; NM_016371
	NM_010476
	NP_001291441; NP_001291442; NP_057455
	NP_034606
	Wikidata
View/Edit Human	View/Edit Mouse

3-keto-steroid reductase is an enzyme that in humans is encoded by the HSD17B7 gene.

The 17-beta-hydroxysteroid dehydrogenase enzyme (EC 1.1.1.62) oxidizes or reduces estrogens and androgens in mammals and regulates the biologic potency of these steroids.[supplied by OMIM]