Hsp27

HSPB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MJH, 3Q9P, 3Q9Q, 2N3J
Identifiers
Aliases	HSPB1, CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27, heat shock protein family B (small) member 1
External IDs	OMIM: 602195; MGI: 96240; HomoloGene: 1180; GeneCards: HSPB1; OMA:HSPB1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	76,304,295 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	135,918,417 bp
RNA expression pattern
	Top expressed in
	ascending aorta; ; right coronary artery; ; mucosa of pharynx; ; gums; ; Descending thoracic aorta; ; Skeletal muscle tissue of rectus abdominis; ; gingival epithelium; ; popliteal artery; ; tibial arteries; ; left coronary artery;
	Top expressed in
	esophagus; ; lip; ; zone of skin; ; muscle of thigh; ; urinary bladder; ; placenta; ; heart; ; quadriceps femoris muscle; ; muscle tissue; ; adrenal gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase C inhibitor activity; protein kinase binding; protein binding; protein kinase C binding; ubiquitin binding; identical protein binding; protein folding chaperone activity; RNA binding; protein homodimerization activity;
Cellular component	nucleus; cytoskeleton; spindle; intracellular anatomical structure; cytosol; extracellular exosome; plasma membrane; Z discdkac; cytoplasm; contractile fiber; focal adhesion; proteasome complex; extracellular matrix; extracellular space; axon cytoplasm;
Biological process	regulation of translational initiation; regulation of mRNA stability; cellular response to vascular endothelial growth factor stimulus; negative regulation of protein serine/threonine kinase activity; positive regulation of endothelial cell chemotaxis; positive regulation of angiogenesis; retina homeostasis; platelet aggregation; intracellular signal transduction; negative regulation of apoptotic signaling pathway; regulation of autophagy; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of interleukin-1 beta production; vascular endothelial growth factor receptor signaling pathway; positive regulation of blood vessel endothelial cell migration; response to unfolded protein; negative regulation of protein kinase activity; regulation of I-kappaB kinase/NF-kappaB signaling; response to virus; negative regulation of apoptotic process; regulation of protein phosphorylation; chaperone-mediated protein folding; anterograde axonal protein transport;
	Sources:Amigo / QuickGO
Orthologs
	3315
	15507
	ENSG00000106211
	ENSMUSG00000004951
	P04792
	P14602
	NM_001540
	NM_013560
	NP_001531
	NP_038588
	Wikidata
View/Edit Human	View/Edit Mouse

Heat shock protein 27 (Hsp27) also known as heat shock protein beta-1 (HSPB1) is a protein that in humans is encoded by the HSPB1 gene.

Hsp27 is a chaperone of the sHsp (small heat shock protein) group among α-crystallin, Hsp20, and others. The common functions of sHsps are chaperone activity, thermotolerance, inhibition of apoptosis, regulation of cell development, and cell differentiation. They also take part in signal transduction.