HTR3A

HTR3A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PIR
Identifiers
Aliases	HTR3A, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3, 5-hydroxytryptamine receptor 3A
External IDs	OMIM: 182139; MGI: 96282; HomoloGene: 671; GeneCards: HTR3A; OMA:HTR3A - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	113,990,313 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	48,822,399 bp
RNA expression pattern
	Top expressed in
	spinal ganglia; ; testicle; ; trigeminal ganglion; ; lymph node; ; islet of Langerhans; ; appendix; ; gingival epithelium; ; muscle layer of sigmoid colon; ; caudate nucleus; ; minor salivary glands;
	Top expressed in
	lumbar spinal ganglion; ; Rostral migratory stream; ; facial motor nucleus; ; medial ganglionic eminence; ; right ventricle; ; embryo; ; carotid body; ; embryo; ; dentate gyrus of hippocampal formation granule cell; ; retinal pigment epithelium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; ligand-gated ion channel activity; serotonin binding; extracellular ligand-gated ion channel activity; serotonin-gated cation-selective channel activity; ion channel activity; transmembrane signaling receptor activity;
Cellular component	cytoplasm; integral component of membrane; postsynaptic membrane; membrane; plasma membrane; synapse; axon; cell junction; soma; serotonin-activated cation-selective channel complex; cleavage furrow; glutamatergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane; integral component of plasma membrane; neuron projection;
Biological process	response to cocaine; cellular response to growth factor stimulus; ion transport; response to ethanol; positive regulation of ion transmembrane transporter activity; signal transduction; ion transmembrane transport; serotonin receptor signaling pathway; chemical synaptic transmission; regulation of membrane potential; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	3359
	15561
	ENSG00000166736
	ENSMUSG00000032269
	P46098
	P23979
	NM_000869; NM_001161772; NM_213621
	NM_001099644; NM_013561
	NP_000860; NP_001155244; NP_998786
	NP_001093114; NP_038589
	Wikidata
View/Edit Human	View/Edit Mouse

5-hydroxytryptamine receptor 3A is a protein that in humans is encoded by the HTR3A gene.

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. The A subunit is the only one that can be expressed alone and forms homomers with a very low single channel conductance of 0.6pS. When combined with the B subunit and expressed as a heteromer, the single channel conductance increases immensely. Alternatively spliced transcript variants encoding different isoforms have been identified.