5-HT6 receptor

HTR6

Identifiers

HTR6, 5-HT6, 5-HT6R, 5-HT6 receptor, 5-hydroxytryptamine receptor 6

External IDs

OMIM: 601109; MGI: 1196627; HomoloGene: 673; GeneCards: HTR6; OMA:HTR6 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1p36.13	Start	19,664,875 bp
Band	1p36.13	End	19,680,966 bp

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)

Band	4 D3\|4 70.57 cM	Start	138,788,419 bp
Band	4 D3\|4 70.57 cM	End	138,802,881 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

beta cell

Brodmann area 10

pancreatic ductal cell

frontal pole

mucosa of urinary bladder

middle frontal gyrus

external globus pallidus

body of tongue

pericardium

inferior ganglion of vagus nerve

Top expressed in

lumbar subsegment of spinal cord

superior frontal gyrus

primary visual cortex

dentate gyrus of hippocampal formation granule cell

ventricular zone

cerebellar cortex

hippocampus proper

neck

digastric muscle

olfactory bulb

More reference expression data


More reference expression data

Gene ontology
Molecular function	histamine receptor activity protein binding G protein-coupled receptor activity signal transducer activity neurotransmitter receptor activity G protein-coupled serotonin receptor activity
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane cilium membrane dendrite
Biological process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger cerebral cortex cell migration positive regulation of TOR signaling signal transduction chemical synaptic transmission G protein-coupled serotonin receptor signaling pathway G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO

Species

Human

Mouse


3362


15565


ENSG00000158748


ENSMUSG00000028747


P50406


Q9R1C8

RefSeq (mRNA)


NM_000871


NM_021358 NM_001377096

RefSeq (protein)


NP_000862


NP_067333 NP_001364025

Location (UCSC)

Chr 1: 19.66 – 19.68 Mb

Chr 4: 138.79 – 138.8 Mb

PubMed search

View/Edit Human

View/Edit Mouse

The 5HT₆ receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT). It is a G protein-coupled receptor (GPCR) that is coupled to G_s and mediates excitatory neurotransmission. HTR6 denotes the human gene encoding for the receptor.