Serine protease HTRA2, mitochondrial

HTRA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LCY, 2PZD
Identifiers
Aliases	HTRA2, Htra2, AI481710, Omi, Prss25, mnd2, PARK13, HtrA serine peptidase 2, MGCA8
External IDs	OMIM: 606441; MGI: 1928676; HomoloGene: 113300; GeneCards: HTRA2; OMA:HTRA2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	74,533,350 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	83,032,254 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; trabecular bone; ; ganglionic eminence; ; apex of heart; ; mucosa of transverse colon; ; granulocyte; ; spleen; ; right ovary; ; ascending aorta; ; left coronary artery;
	Top expressed in
	renal corpuscle; ; medullary collecting duct; ; fossa; ; endothelial cell of lymphatic vessel; ; condyle; ; fetal liver hematopoietic progenitor cell; ; ureter; ; seminal vesicula; ; endocardial cushion; ; sciatic nerve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; protein binding; serine-type peptidase activity; serine-type endopeptidase activity; hydrolase activity; peptidase activity; identical protein binding;
Cellular component	integral component of membrane; cytosol; endoplasmic reticulum membrane; membrane; mitochondrial membranes; mitochondrial intermembrane space; endoplasmic reticulum; mitochondrion; CD40 receptor complex; cytoplasmic side of plasma membrane; chromatin; cytoskeleton; nucleus; serine-type endopeptidase complex;
Biological process	cellular response to retinoic acid; cellular response to heat; positive regulation of cell death; ceramide metabolic process; cellular response to interferon-beta; regulation of multicellular organism growth; positive regulation of protein targeting to mitochondrion; execution phase of apoptosis; adult locomotory behavior; cellular response to growth factor stimulus; pentacyclic triterpenoid metabolic process; mitochondrion organization; negative regulation of cell cycle; neuron development; protein autoprocessing; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; negative regulation of cell death; intrinsic apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; regulation of autophagy of mitochondrion; intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of apoptotic process; forebrain development; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; response to herbicide; adult walking behavior; negative regulation of neuron death; apoptotic process; ageing; proteolysis; positive regulation of mitochondrion organization; cellular response to oxidative stress; negative regulation of mitophagy in response to mitochondrial depolarization; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; protein homotrimerization;
	Sources:Amigo / QuickGO
Orthologs
	27429
	64704
	ENSG00000115317
	ENSMUSG00000068329
	O43464
	Q9JIY5
	NM_013247; NM_145074; NM_001321727; NM_001321728
	NM_019752
	NP_001308656; NP_001308657; NP_037379; NP_659540
	NP_062726
	Wikidata
View/Edit Human	View/Edit Mouse

Serine protease HTRA2, mitochondrial is an enzyme that in humans is encoded by the HTRA2 gene. This protein is involved in caspase-dependent apoptosis and in Parkinson's disease.