| HUWE1 |
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| Identifiers |
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| Aliases | HUWE1, ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MULE, URE-B1, UREB1, HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase, HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1, MRXST |
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| External IDs | OMIM: 300697; MGI: 1926884; HomoloGene: 45994; GeneCards: HUWE1; OMA:HUWE1 - orthologs |
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| Gene location (Mouse) |
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| | Chr. | X chromosome (mouse) |
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| | Band | X|X F3 | Start | 151,800,807 bp |
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| End | 151,935,417 bp |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - skin of leg
- skin of abdomen
- right lobe of thyroid gland
- anterior pituitary
- right ovary
- left lobe of thyroid gland
- left ovary
- ganglionic eminence
- right hemisphere of cerebellum
- ectocervix
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| | Top expressed in | - tail of embryo
- genital tubercle
- neural layer of retina
- ventricular zone
- entorhinal cortex
- suprachiasmatic nucleus
- dentate gyrus of hippocampal formation granule cell
- epiblast
- substantia nigra
- perirhinal cortex
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| | More reference expression data |
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| BioGPS | |
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| Wikidata |
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E3 ubiquitin-protein ligase HUWE1 is an enzyme that in humans is encoded by the HUWE1 gene.
It performs the third step (ligation) in binding ubiquitin to proteins in a process called ubiquitination which tags the proteins for disposal.
Human genetic studies that implicate HUWE1 in intellectual disability. Additional research suggests HUWE1 has implications in cancer research.
