Hailey–Hailey disease

Hailey–Hailey disease
Other namesFamilial benign chronic pemphigus
Left axilla mild, uninfected Hailey–Hailey lesion
SpecialtyMedical genetics 
SymptomsRashes and blisters on the skin, could be painful to the touch with a possibility of acantholysis, erythema and hyperkeratosis.
Usual onsetLate teenage years or 30s-40s
DurationChronic
CausesMutations in the ATP2C1 gene
Risk factorsFamily history
Named afterHugh Edward Hailey and William Howard Hailey

Hailey–Hailey disease (HHD), or familial benign chronic pemphigus:559 or familial benign pemphigus,:622 was originally described by the Hailey brothers (Hugh Edward and William Howard) in 1939. It is a genetic disorder that causes blisters to form on the skin.