Helena Cassadine

In-universe information
In-universe information
Other names	Helena Romanov; Helena Anhalt Cassadine;
Occupation	Socialite; Terrorist;
Family	Cassadine
Parents	Basil Romanov; Agatha Romanov;
Spouse	Mikkos Cassadine (195?–1981)
Sons	Stavros Cassadine; Stefan Cassadine; Valentin Cassadine;
Daughters	Irina Cassadine
Stepdaughters	Alexis Davis; Kristina Cassadine;
Grandsons	Nikolas Cassadine
Granddaughters	Charlotte Cassadine
Other relatives	Spencer Cassadine; Ace Cassadine; Sam Morgan; Kristina Davis; Molly Lansing; Danny Morgan;

Helena Cassadine
Helena Cassadine
General Hospital character
	Constance Towers as Helena Cassadine
Portrayed by	Elizabeth Taylor (1981); Dimitra Arliss (1996); Constance Towers (1997–2023);
Duration	1981; 1996–2007; 2009–2017; 2019–2020; 2022–2023;
First appearance	November 16, 1981
Last appearance	May 4, 2023
Classification	Former; guest
Created by	Gloria Monty; Thom Racina;
Introduced by	Gloria Monty (1981); Wendy Riche (1996); Jill Farren Phelps (2009); Frank Valentini (2019);
Book appearances	The Secret Life of Damian Spinelli
Other names	Helena Romanov; Helena Anhalt Cassadine;
In-universe information
Other names	Helena Romanov; Helena Anhalt Cassadine;
Occupation	Socialite; Terrorist;
Family	Cassadine
Parents	Basil Romanov; Agatha Romanov;
Spouse	Mikkos Cassadine (195?–1981)
Sons	Stavros Cassadine; Stefan Cassadine; Valentin Cassadine;
Daughters	Irina Cassadine
Stepdaughters	Alexis Davis; Kristina Cassadine;
Grandsons	Nikolas Cassadine
Granddaughters	Charlotte Cassadine
Other relatives	Spencer Cassadine; Ace Cassadine; Sam Morgan; Kristina Davis; Molly Lansing; Danny Morgan;

Helena Cassadine is a fictional character who is the main antagonist of the American soap opera General Hospital, famously originated by film actress Elizabeth Taylor in November 1981. After a brief stint by Dimitra Arliss in 1996, Constance Towers took over the role in 1997 and has returned — for periods of varying length — nearly every year since.