Type I cytokine receptor
| Type I cytokine receptor, cytokine-binding domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | TypeI_recpt_CBD | ||||||||
| Pfam | PF09240 | ||||||||
| Pfam clan | CL0159 | ||||||||
| InterPro | IPR015321 | ||||||||
| SCOP2 | 1n26 / SCOPe / SUPFAM | ||||||||
| Membranome | 2 | ||||||||
| |||||||||
Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.
The common cytokine-binding domain is related to the Fibronectin type III domain.