Histamine H4 receptor

HRH4
Identifiers
Aliases	HRH4, AXOR35, BG26, GPCR105, GPRv53, H4, H4R, HH4R, histamine receptor H4
External IDs	OMIM: 606792; MGI: 2429635; HomoloGene: 11002; GeneCards: HRH4; OMA:HRH4 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	24,479,961 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	13,155,939 bp
RNA expression pattern
	Top expressed in
	monocyte; ; bone marrow; ; gonad; ; tibialis anterior muscle; ; blood; ; appendix; ; deltoid muscle; ; duodenum; ; right lobe of liver; ; lymph node;
	Top expressed in
	embryo; ; spermatocyte; ; spermatid; ; vastus lateralis muscle; ; testicle; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; histamine receptor activity; G protein-coupled serotonin receptor activity; G protein-coupled acetylcholine receptor activity; neurotransmitter receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; dendrite;
Biological process	positive regulation of cytosolic calcium ion concentration; regulation of MAPK cascade; signal transduction; inflammatory response; negative regulation of adenylate cyclase activity; G protein-coupled receptor signaling pathway; biological process; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; chemical synaptic transmission; G protein-coupled serotonin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	59340
	225192
	ENSG00000134489
	ENSMUSG00000037346
	Q9H3N8
	Q91ZY2
	NM_001143828; NM_001160166; NM_021624
	NM_153087
	NP_001137300; NP_001153638; NP_067637
	NP_694727
	Wikidata
View/Edit Human	View/Edit Mouse

The histamine H₄ receptor, like the other three histamine receptors, is a member of the G protein-coupled receptor superfamily that in humans is encoded by the HRH4 gene.