Holocytochrome-c synthase
| holocytochrome-c synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Holocytochrome-c synthase monomer, Thermus thermophilus | |||||||||
| Identifiers | |||||||||
| EC no. | 4.4.1.17 | ||||||||
| CAS no. | 75139-03-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| Cytochrome c/c1 heme lyase | |||||||||
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| Identifiers | |||||||||
| Symbol | Cyto_heme_lyase | ||||||||
| Pfam | PF01265 | ||||||||
| InterPro | IPR000511 | ||||||||
| PROSITE | PDOC00647 | ||||||||
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The enzyme holocytochrome-c synthase (EC 4.4.1.17) catalyzes the chemical reaction
- holocytochrome c apocytochrome c + heme
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is holocytochrome-c apocytochrome-c-lyase (heme-forming). Other names in common use include cytochrome c heme-lyase, holocytochrome c synthetase, and holocytochrome-c apocytochrome-c-lyase. This enzyme participates in porphyrin and chlorophyll metabolism.
Cytochrome c heme-lyase (CCHL) and cytochrome Cc1 heme-lyase (CC1HL) are mitochondrial enzymes that catalyze the covalent attachment of a heme group on two cysteine residues of cytochrome c and c1. These two enzymes are functionally and evolutionary related. There are two conserved regions, the first is located in the central section and the second in the C-terminal section. Both patterns contain conserved histidine, tryptophan and acidic residues which could be important for the interaction of the enzymes with the apoproteins and/or the heme group.
The human enzyme, HCCS, processes both cytochromes c and c1.