House of Yes: Live from House of Blues is a live album and video by the English progressive rock band Yes, released on 25 September 2000 by Eagle Records in the United Kingdom and by Beyond Music in the United States. It is a recording of the band's performance at the House of Blues at Mandalay Bay in Las Vegas on 31 October 1999 during their world tour supporting their eighteenth studio album The Ladder. By the time of the album's release, guitarist Billy Sherwood and keyboardist Igor Khoroshev were already out of the band, reducing Yes to a four-piece.
The album peaked at No. 154 on the UK Albums Chart and failed to chart in the US. A DVD of the concert was also released in 2000.