Hsp70
| Hsp70 protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Structure of the ATPase fragment of a 70K heat-shock cognate protein. | |||||||||
| Identifiers | |||||||||
| Symbol | HSP70 | ||||||||
| Pfam | PF00012 | ||||||||
| Pfam clan | CL0108 | ||||||||
| InterPro | IPR013126 | ||||||||
| PROSITE | PDOC00269 | ||||||||
| SCOP2 | 3hsc / SCOPe / SUPFAM | ||||||||
| |||||||||
The 70 kilodalton heat shock proteins (Hsp70s or DnaK) are a family of conserved ubiquitously expressed heat shock proteins. Proteins with similar structure exist in virtually all living organisms and play crucial roles in the development of cancer, neurodegeneration, apoptosis, regulating sleep, and much more. Intracellularly localized Hsp70s are an important part of the cell's machinery for protein folding, performing chaperoning functions, and helping to protect cells from the adverse effects of physiological stresses. Additionally, membrane-bound Hsp70s have been identified as a potential target for cancer therapies and their extracellularly localized counterparts have been identified as having both membrane-bound and membrane-free structures. There is lot of potential in the Hsp70 protein as a key therapeutic target for developing new drugs for the treatment of sleep disorders, cancer, neurodegeneration, and other related pathological conditions.