HuD (protein)

ELAVL4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FXL, 1G2E
Identifiers
Aliases	ELAVL4, HUD, PNEM, HuD, ELAV like neuron-specific RNA binding protein 4, ELAV like RNA binding protein 4
External IDs	OMIM: 168360; MGI: 107427; HomoloGene: 40729; GeneCards: ELAVL4; OMA:ELAVL4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	50,203,772 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	110,351,909 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; ganglionic eminence; ; Brodmann area 23; ; middle temporal gyrus; ; Pons; ; Brodmann area 46; ; parietal lobe; ; postcentral gyrus; ; superior frontal gyrus; ; sperm;
	Top expressed in
	habenula; ; ventral tegmental area; ; medial vestibular nucleus; ; superior cervical ganglion; ; trigeminal ganglion; ; ganglionic eminence; ; neural tube; ; pontine nuclei; ; medial ganglionic eminence; ; Rostral migratory stream;
	More reference expression data
	More reference expression data
Orthologs
	1996
	15572
	ENSG00000162374
	ENSMUSG00000028546
	P26378
	Q61701
NM_001144774; NM_001144775; NM_001144776; NM_001144777; NM_001294348;
	NM_021952; NM_001324208; NM_001324209; NM_001324212; NM_001324213; NM_001324214; NM_001324215; NM_001324216; NM_001324217
NM_001038698; NM_001163397; NM_001163399; NM_010488; NM_001347178;
	NM_001357190
NP_001138246; NP_001138247; NP_001138248; NP_001138249; NP_001281277;
	NP_001311137; NP_001311138; NP_001311141; NP_001311142; NP_001311143; NP_001311144; NP_001311145; NP_001311146; NP_068771
NP_001033787; NP_001156869; NP_001156871; NP_001334107; NP_034618;
	NP_001344119
	Wikidata
View/Edit Human	View/Edit Mouse

HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene.

The HuD/ELAVL4 protein is an RNA-binding protein. HuD contains three RRM protein domains, enabling RNA binding.

HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.