Hydrocodone/ibuprofen
| Combination of | |
|---|---|
| Hydrocodone | Opioid analgesic |
| Ibuprofen | Non-steroidal anti-inflammatory drug |
| Clinical data | |
| Trade names | Ibudone, Reprexain, Vicoprofen |
| AHFS/Drugs.com | Professional Drug Facts |
| MedlinePlus | a601006 |
| License data | |
| Dependence liability | Moderate |
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | >80% |
| Metabolism | for hydrocodone: liver, CYP3A4; for ibuprofen: liver, CYP2C9 |
| Elimination half-life | for hydrocodone: 228-294 mins (3.8-4.9 hrs); for ibuprofen: 108-120 mins (1.8-2 hrs) |
| Excretion | for hydrocodone: urinary; for ibuprofen: urine primarily (<1% unchanged) |
| Identifiers | |
| KEGG | |
| CompTox Dashboard (EPA) | |
| (verify) | |
Hydrocodone/ibuprofen (INNs), sold under the brand name Vicoprofen, is a fixed-dose combination analgesic medication used in short-term therapy to relieve severe pain. Vicoprofen combines the analgesic and antitussive properties of hydrocodone with the analgesic, anti-inflammatory, and antipyretic properties of ibuprofen. In contrast to hydrocodone/acetaminophen combination analgesics such as Vicodin, this hydrocodone/ibuprofen avoids some of the liver toxicity which may occur from acetaminophen, but still presents significant dangers in hydrocodone overdose, namely respiratory depression. Vicoprofen is supplied in a fixed dose combination tablet which contains hydrocodone bitartrate, USP 7.5 mg with ibuprofen, USP 200 mg. Additional strengths of generic Vicoprofen are now available, in combinations of 5 mg/200 mg and 10 mg/200 mg respectively.