Hydroxyethyl starch

Hydroxyethyl starch
Clinical data
Trade namesHespan, Voluven, Volulyte, Tetrahes, Hestar
Routes of
administration		Intravenous
ATC code
Pharmacokinetic data
Elimination half-life1.4 hrs
ExcretionRenal
Identifiers
CAS Number
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.120.749
Chemical and physical data
Molar mass130–200 kg/mol (typical)
3D model (JSmol)
  • O(CCO)[C@H]1O[C@@H]([C@@H](OCCO)[C@H](OCCO)[C@H]1OCCO)COCCO.OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
  • InChI=1S/C16H32O11.C6H12O6/c17-1-6-22-11-12-13(23-7-2-18)14(24-8-3-19)15(25-9-4-20)16(27-12)26-10-5-21;7-1-2-3(8)4(9)5(10)6(11)12-2/h12-21H,1-11H2;2-11H,1H2/t12-,13-,14+,15-,16+;2-,3-,4+,5-,6+/m11/s1 Y
  • Key:DNZMDASEFMLYBU-RNBXVSKKSA-N Y
  (verify)

Hydroxyethyl starch (HES/HAES), sold under the brand name Voluven among others, is a nonionic starch derivative, used as a volume expander in intravenous therapy. The use of HES on critically ill patients is associated with an increased risk of death and kidney problems.

HES is a general term and can be sub-classified according to average molecular weight, molar substitution, concentration, C2/C6 ratio and Maximum Daily Dose. The European Medicines Agency commenced in June 2013 the process of agreeing to reduced indications which was completed in October 2013. The process of full withdrawal in the EU was expected to complete in 2018.

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