Vitamin D deficiency

Vitamin D deficiency
Other namesHypovitaminosis D
The normal process of Vitamin D absorption
SpecialtyEndocrinology 
SymptomsUsually asymptomatic
ComplicationsRickets, osteomalacia, other associated disorders
CausesLack of vitamin D, inadequate sunlight exposure
Risk factorsAge, people with dark skin, obesity, malabsorption, bariatric surgery, breastfed infants
Diagnostic methodMeasuring the concentration of calcifediol in the blood
PreventionSufficient sunlight exposure, dietary intake
TreatmentSupplements
MedicationCholecalciferol, ergocalciferol, calcifediol
FrequencySevere deficiency (<30 nmol/L): Europe 13%, US 5.9%, Canada 7.4%. Deficiency (<50 nmol/L): Europe 40%, US 24%, Canada 37%

Vitamin D deficiency or hypovitaminosis D is a vitamin D level that is below normal. It most commonly occurs in people when they have inadequate exposure to sunlight, particularly sunlight with adequate ultraviolet B rays (UVB). Vitamin D deficiency can also be caused by inadequate nutritional intake of vitamin D; disorders that limit vitamin D absorption; and disorders that impair the conversion of vitamin D to active metabolites, including certain liver, kidney, and hereditary disorders. Deficiency impairs bone mineralization, leading to bone-softening diseases, such as rickets in children. It can also worsen osteomalacia and osteoporosis in adults, increasing the risk of bone fractures. Muscle weakness is also a common symptom of vitamin D deficiency, further increasing the risk of falls and bone fractures in adults. Vitamin D deficiency is associated with the development of schizophrenia.

Vitamin D can be synthesized in the skin under exposure to UVB from sunlight. Oily fish, such as salmon, herring, and mackerel, are also sources of vitamin D, as are mushrooms. Milk is often fortified with vitamin D; sometimes bread, juices, and other dairy products are fortified with vitamin D. Many multivitamins contain vitamin D in different amounts.