ICA1

ICA1
Identifiers
Aliases	ICA1, ICA69, ICAp69, islet cell autoantigen 1
External IDs	OMIM: 147625; MGI: 96391; HomoloGene: 7777; GeneCards: ICA1; OMA:ICA1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	8,778,488 bp
RNA expression pattern
	n/a
	Top expressed in
	spermatid; ; saccule; ; seminiferous tubule; ; lacrimal gland; ; islet of Langerhans; ; zygote; ; submandibular gland; ; otic vesicle; ; seminal vesicula; ; parotid gland;
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein domain specific binding; molecular function;
Cellular component	Golgi membrane; cell junction; transport vesicle membrane; synapse; synaptic vesicle membrane; secretory granule membrane; membrane; cytoplasmic vesicle; cytoplasm; Golgi apparatus; cytosol; intracellular membrane-bounded organelle;
Biological process	neurotransmitter transport; regulation of insulin secretion;
	Sources:Amigo / QuickGO
Orthologs
	3382
	15893
	ENSG00000003147
	ENSMUSG00000062995
	Q05084
	P97411
	NM_001136020; NM_001276478; NM_004968; NM_022307; NM_022308
	NM_001252266; NM_010492
NP_001129492; NP_001263407; NP_004959; NP_071682; NP_001337748;
	NP_001337749; NP_001337750; NP_001337752; NP_001337753; NP_001337754; NP_001337755; NP_001337756; NP_001337757; NP_001337758; NP_001337759; NP_001337760; NP_001337761; NP_001337762; NP_001337763; NP_001337764; NP_001337765; NP_001337766; NP_001337767
	NP_001239195; NP_034622
	Wikidata
View/Edit Human	View/Edit Mouse

Islet cell autoantigen 1 is a protein that in humans is encoded by the ICA1 gene.

This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjögren's syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.