ICAM5

ICAM5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BN3, 4OI9, 4OIA, 4OIB
Identifiers
Aliases	ICAM5, TLCN, TLN, intercellular adhesion molecule 5
External IDs	OMIM: 601852; MGI: 109430; HomoloGene: 2447; GeneCards: ICAM5; OMA:ICAM5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,296,778 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	20,950,332 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; nucleus accumbens; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; caudate nucleus; ; frontal pole; ; hippocampus proper;
	Top expressed in
	entorhinal cortex; ; perirhinal cortex; ; CA3 field; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; primary visual cortex; ; hippocampus proper; ; Region I of hippocampus proper; ; nucleus accumbens; ; prefrontal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	integrin binding; protein binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	cell adhesion; phagocytosis; regulation of immune response; extracellular matrix organization; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	7087
	15898
	ENSG00000105376
	ENSMUSG00000032174
	Q9UMF0
	Q60625
	NM_003259
	NM_008319
	NP_003250
	NP_032345
	Wikidata
View/Edit Human	View/Edit Mouse

Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ICAM5 gene.

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.

Studies mentioned a role for ICAM5 in cell adhesion and cell signalling and dysregulation and disfunction of it will increase the risk of breast cancer. Study of the association between polymorphisms and breast cancer has been shown that ICAM5 rs1056538 and ICAM5 rs281439 variants might contribute the most in the development of breast cancer.