ICK (gene)

CILK1
Identifiers
Aliases	CILK1, ECO, LCK2, MRK, intestinal cell (MAK-like) kinase, intestinal cell kinase, EJM10, ICK, ciliogenesis associated kinase 1, hICK
External IDs	OMIM: 612325; MGI: 1934157; HomoloGene: 69218; GeneCards: CILK1; OMA:CILK1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	53,061,824 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	78,079,389 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; left adrenal gland; ; left adrenal cortex; ; right adrenal cortex; ; ganglionic eminence; ; olfactory zone of nasal mucosa; ; rectum; ; placenta; ; Achilles tendon; ; C1 segment;
	Top expressed in
	trigeminal ganglion; ; Rostral migratory stream; ; epithelium of stomach; ; Paneth cell; ; gastrula; ; external carotid artery; ; genital tubercle; ; ciliary body; ; substantia nigra; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; magnesium ion binding;
Cellular component	ciliary basal body; cytosol; cell projection; ciliary tip; cytoskeleton; cilium; ciliary base; nucleus; cytoplasm; fibrillar center;
Biological process	intracellular signal transduction; phosphorylation; multicellular organism development; protein phosphorylation; cell projection organization; signal transduction; intraciliary anterograde transport; intraciliary retrograde transport; cilium assembly; regulation of gene expression; intraciliary transport;
	Sources:Amigo / QuickGO
Orthologs
	22858
	56542
	ENSG00000112144
	ENSMUSG00000009828
	Q9UPZ9
	Q9JKV2
NM_014920; NM_016513; NM_001375397; NM_001375398; NM_001375399;
	NM_001375400; NM_001375401; NM_001375402; NM_173041
	NM_001163780; NM_019987
NP_055735; NP_057597; NP_001362326; NP_001362327; NP_001362328;
	NP_001362329; NP_001362330; NP_001362331
	NP_001157252; NP_064371
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase, Intestinal cell kinase or ICK is an enzyme that in humans is encoded by the ICK gene.

Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified.