IDH3A

IDH3A
Identifiers
Aliases	IDH3A, isocitrate dehydrogenase 3 (NAD(+)) alpha, isocitrate dehydrogenase (NAD(+)) 3 alpha, isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha, RP90
External IDs	OMIM: 601149; MGI: 1915084; HomoloGene: 4037; GeneCards: IDH3A; OMA:IDH3A - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	78,171,945 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	54,511,945 bp
RNA expression pattern
	Top expressed in
	right auricle of heart; ; right ventricle; ; left ventricle; ; rectum; ; apex of heart; ; prefrontal cortex; ; muscle of thigh; ; gastrocnemius muscle; ; biceps brachii; ; nucleus accumbens;
	Top expressed in
	sternocleidomastoid muscle; ; triceps brachii muscle; ; temporal muscle; ; digastric muscle; ; vastus lateralis muscle; ; right ventricle; ; atrioventricular valve; ; intercostal muscle; ; brown adipose tissue; ; medial head of gastrocnemius muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; oxidoreductase activity; NAD binding; metal ion binding; magnesium ion binding; isocitrate dehydrogenase (NAD+) activity;
Cellular component	myelin sheath; mitochondrial matrix; mitochondrion; nucleus;
Biological process	tricarboxylic acid cycle; carbohydrate metabolic process; isocitrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	3419
	67834
	ENSG00000166411
	ENSMUSG00000032279
	P50213
	Q9D6R2
	NM_005530
	NM_029573
	NP_005521
	NP_083849
	Wikidata
View/Edit Human	View/Edit Mouse

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (IDH3α) is an enzyme that in humans is encoded by the IDH3A gene.

Isocitrate dehydrogenases (IDHs) catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008]