IFI30

IFI30
Identifiers
Aliases	IFI30, GILT, IFI-30, IP30, IP-30, lysosomal thiol reductase, IFI30 lysosomal thiol reductase
External IDs	OMIM: 604664; MGI: 2137648; HomoloGene: 38171; GeneCards: IFI30; OMA:IFI30 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	18,178,117 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,219,307 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; appendix; ; spleen; ; upper lobe of left lung; ; right lung; ; lymph node; ; duodenum; ; right adrenal cortex;
	Top expressed in
	spleen; ; duodenum; ; colon; ; yolk sac; ; jejunum; ; stomach; ; ileum; ; thymus; ; zone of skin; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; protein binding; oxidoreductase activity, acting on a sulfur group of donors;
Cellular component	extracellular region; cell junction; lysosomal lumen; intracellular membrane-bounded organelle; lysosome; cytosol;
Biological process	interferon-gamma-mediated signaling pathway; immune system process; antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of exogenous peptide antigen via MHC class I;
	Sources:Amigo / QuickGO
Orthologs
	10437
	65972
	ENSG00000216490
	ENSMUSG00000031838
	P13284
	Q9ESY9
	NM_006332
	NM_023065
	NP_006323
	NP_075552
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-interferon-inducible lysosomal thiol reductase is an enzyme that, in humans, is encoded by the IFI30 gene.

The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing.