IFIT2

IFIT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4G1T
Identifiers
Aliases	IFIT2, G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, P54, cig42, interferon induced protein with tetratricopeptide repeats 2, ISG-54
External IDs	OMIM: 147040; MGI: 99449; HomoloGene: 1187; GeneCards: IFIT2; OMA:IFIT2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	89,309,271 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	34,553,819 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; inferior ganglion of vagus nerve; ; trigeminal ganglion; ; subthalamic nucleus; ; visceral pleura; ; white blood cell; ; monocyte; ; external globus pallidus; ; parietal pleura; ; spinal ganglia;
	Top expressed in
	iris; ; mammillary body; ; lumbar spinal ganglion; ; decidua; ; endothelial cell of lymphatic vessel; ; blood; ; ciliary body; ; sciatic nerve; ; medial geniculate nucleus; ; medial dorsal nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	cytoplasm; cytosol; endoplasmic reticulum;
Biological process	apoptotic process; positive regulation of apoptotic process; response to virus; innate immune response; defense response to virus; negative regulation of protein binding; apoptotic mitochondrial changes; type I interferon signaling pathway; cellular response to interferon-alpha; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	3433
	15958
	ENSG00000119922
	ENSMUSG00000045932
	P09913
	Q64112
	NM_001547
	NM_008332; NM_001355262
	NP_001538
	NP_032358; NP_001342191
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon-induced protein with tetratricopeptide repeats 2 (commonly termed IFIT2) is a protein that in humans is directed to be produced by the IFIT2 gene. Previously, this gene was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 gene and the protein that it directs to be produced was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 protein. The IFIT2 gene is one of the many genes that are stimulated by type 1 interferons to form their messenger RNAs and thereby their product proteins. Consequently, the IFIT2 gene is classified as one of the many type 1 interferon-stimulated genes.