IFNK

IFNK
Identifiers
Aliases	IFNK, IFNT1, INFE1, interferon kappa
External IDs	OMIM: 615326; MGI: 2683287; HomoloGene: 36384; GeneCards: IFNK; OMA:IFNK - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	27,526,498 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	35,154,005 bp
RNA expression pattern
	Top expressed in
	testicle; ; Achilles tendon; ; corpus callosum; ; epithelium of colon; ; monocyte; ; skeletal muscle tissue; ; blood; ; muscle of thigh; ; cervix; ; respiratory system;
	Top expressed in
	blastocyst; ; embryo; ; morula; ; placenta; ; tail of embryo; ; yolk sac; ; uterus; ; liver; ; stomach; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; type I interferon receptor binding; cytokine receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	natural killer cell activation involved in immune response; B cell differentiation; defense response; response to virus; natural killer cell activation; B cell proliferation; regulation of transcription, DNA-templated; humoral immune response; adaptive immune response; positive regulation of peptidyl-serine phosphorylation of STAT protein; defense response to virus; response to exogenous dsRNA; negative regulation of cell population proliferation; cytokine-mediated signaling pathway; positive regulation of innate immune response; T cell activation involved in immune response; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	56832
	387510
	ENSG00000147896
	ENSMUSG00000042993
	Q9P0W0
	Q7TSL0
	NM_020124
	NM_199157
	NP_064509
	NP_954608
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon kappa or IFN-kappa is a protein that in humans is encoded by the IFNK gene. Through different clinical studies, Interferon kappa has been assumed to play a role in controlling immune cell activity. It has been determined that this is a cytokine that gives cells species-specific resistance against viral infection. Interferon-stimulated response element signaling has also been hypothesized to be induced. This is because it has the ability to directly regulate the release of cytokines by monocytes and dendritic cells. It has also been discovered to bind heparin.