Interferon Lambda 4

IFNL4
Identifiers
Aliases	IFNL4, IFNAN, interferon, lambda 4 (gene/pseudogene), interferon lambda 4 (gene/pseudogene)
External IDs	OMIM: 615090; GeneCards: IFNL4; OMA:IFNL4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	39,248,856 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; prefrontal cortex; ; superior frontal gyrus; ; Hypothalamus; ; substantia nigra; ; anterior cingulate cortex; ; temporal lobe; ; Amygdala; ; hippocampus proper;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; signaling receptor binding;
Cellular component	cytoplasm; extracellular region; extracellular space;
Biological process	innate immune response; positive regulation of immune response; regulation of T cell activation; receptor signaling pathway via JAK-STAT; defense response to virus; tyrosine phosphorylation of STAT protein; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	101180976
	n/a
	ENSG00000272395
	n/a
	K9M1U5
	n/a
	NM_001276254
	n/a
	NP_001263183
	n/a
	Wikidata
View/Edit Human

Interferon lambda 4 (gene symbol: IFNL4) is one of the most recently discovered human genes and the newest addition to the interferon lambda protein family. This gene encodes the IFNL4 protein, which is involved in immune response to viral infection.

IFNL4 is similar to three neighboring genes (IFNL1, IFNL2 and IFNL3) in that proteins encoded by these genes bind to a shared co-receptor complex. Formation of this complex leads to activation of the JAK-STAT signalling pathway and upregulation of numerous interferon-stimulated genes. Genetics variants within or near this gene have been linked to clearance of hepatitis C virus (HCV) infection and other phenotypes.