IGFBP5

IGFBP5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BOE, 1H59
Identifiers
Aliases	IGFBP5, IBP5, insulin like growth factor binding protein 5
External IDs	OMIM: 146734; MGI: 96440; HomoloGene: 56489; GeneCards: IGFBP5; OMA:IGFBP5 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	216,695,549 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	72,914,043 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; urethra; ; saphenous vein; ; nipple; ; vena cava; ; cardia; ; pylorus; ; canal of the cervix; ; left uterine tube; ; right ovary;
	Top expressed in
	ciliary body; ; external carotid artery; ; molar; ; lactiferous gland; ; saccule; ; extraocular muscle; ; ankle; ; otic placode; ; otic vesicle; ; internal carotid artery;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	fibronectin binding; insulin-like growth factor binding; growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding; protein binding;
Cellular component	insulin-like growth factor ternary complex; extracellular region; insulin-like growth factor binding protein complex; endoplasmic reticulum lumen; extracellular space;
Biological process	negative regulation of smooth muscle cell proliferation; negative regulation of translation; positive regulation of protein kinase B signaling; intracellular signal transduction; negative regulation of growth; glucose homeostasis; female pregnancy; cellular response to organic cyclic compound; negative regulation of smooth muscle cell migration; negative regulation of osteoblast differentiation; regulation of glucose metabolic process; negative regulation of cell migration; positive regulation of insulin-like growth factor receptor signaling pathway; regulation of cell growth; osteoblast differentiation; response to growth hormone; glucose metabolic process; negative regulation of insulin-like growth factor receptor signaling pathway; hair follicle morphogenesis; regulation of growth; negative regulation of muscle tissue development; striated muscle cell differentiation; lung alveolus development; negative regulation of skeletal muscle hypertrophy; type B pancreatic cell proliferation; cellular response to cAMP; signal transduction; mammary gland involution; ageing; post-translational protein modification; positive regulation of vascular associated smooth muscle cell proliferation; positive regulation of vascular associated smooth muscle cell migration; regulation of insulin-like growth factor receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3488
	16011
	ENSG00000115461
	ENSMUSG00000026185
	P24593
	Q07079
	NM_000599
	NM_010518
	NP_000590
	NP_034648
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin-like growth factor-binding protein 5 (IBF-5) is a protein that in humans is encoded by the IGFBP5 gene. An IGFBP5 gene was recently identified as being important for adaptation to varying water salinity in fish.