IKK2

IKBKB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KIK, 3BRT, 3BRV, 4E3C
Identifiers
Aliases	IKBKB, IKK-beta, IKK2, IKKB, IMD15, NFKBIKB, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, inhibitor of nuclear factor kappa B kinase subunit beta, IMD15A, IMD15B
External IDs	OMIM: 603258; MGI: 1338071; HomoloGene: 7782; GeneCards: IKBKB; OMA:IKBKB - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	42,332,460 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	23,196,605 bp
RNA expression pattern
	Top expressed in
	spleen; ; granulocyte; ; right lobe of thyroid gland; ; right uterine tube; ; skin of leg; ; skin of abdomen; ; minor salivary glands; ; left lobe of thyroid gland; ; tonsil; ; vagina;
	Top expressed in
	mesenteric lymph nodes; ; blood; ; Paneth cell; ; crypt of lieberkuhn of small intestine; ; hair follicle; ; molar; ; medullary collecting duct; ; superior cervical ganglion; ; stroma of bone marrow; ; spleen;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; IkappaB kinase activity; nucleotide binding; protein homodimerization activity; scaffold protein binding; kinase activity; protein binding; ATP binding; protein kinase binding; protein heterodimerization activity; protein serine/threonine kinase activity; identical protein binding;
Cellular component	membrane; membrane raft; CD40 receptor complex; cytoplasmic side of plasma membrane; nucleus; IkappaB kinase complex; cytoplasm; cytosol;
Biological process	phosphorylation; regulation of tumor necrosis factor-mediated signaling pathway; cellular response to tumor necrosis factor; response to virus; regulation of phosphorylation; negative regulation of apoptotic process; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; Fc-epsilon receptor signaling pathway; positive regulation of transcription, DNA-templated; protein phosphorylation; negative regulation of bicellular tight junction assembly; stress-activated MAPK cascade; positive regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of myosin-light-chain-phosphatase activity; innate immune response; inflammatory response; I-kappaB kinase/NF-kappaB signaling; cortical actin cytoskeleton organization; positive regulation of transcription by RNA polymerase II; regulation of establishment of endothelial barrier; I-kappaB phosphorylation; tumor necrosis factor-mediated signaling pathway; positive regulation of NF-kappaB transcription factor activity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; anatomical structure morphogenesis; protein localization to plasma membrane; MyD88-independent toll-like receptor signaling pathway; peptidyl-serine phosphorylation; interleukin-1-mediated signaling pathway; viral process;
	Sources:Amigo / QuickGO
Orthologs
	3551
	16150
	ENSG00000104365
	ENSMUSG00000031537
	O14920
	O88351
	NM_001190720; NM_001190721; NM_001190722; NM_001242778; NM_001556
	NM_001159774; NM_010546
	NP_001177649; NP_001229707; NP_001547
	NP_001153246; NP_034676
	Wikidata
View/Edit Human	View/Edit Mouse

IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta) gene.