IKBKE

IKBKE
Identifiers
Aliases	IKBKE, IKK-E, IKK-i, IKKE, IKKI, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon, inhibitor of nuclear factor kappa B kinase subunit epsilon
External IDs	OMIM: 605048; MGI: 1929612; HomoloGene: 23168; GeneCards: IKBKE; OMA:IKBKE - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	206,496,889 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	131,207,344 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; granulocyte; ; monocyte; ; blood; ; lymph node; ; bone marrow cells; ; appendix; ; mucosa of esophagus; ; tonsil; ; mucosa of transverse colon;
	Top expressed in
	mesenteric lymph nodes; ; crypt of lieberkuhn of small intestine; ; thymus; ; stroma of bone marrow; ; granulocyte; ; jejunum; ; duodenum; ; ileum; ; blood; ; choroidal fissure;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; IkappaB kinase activity; nucleotide binding; K48-linked polyubiquitin modification-dependent protein binding; kinase activity; protein serine/threonine kinase activity; NF-kappaB-inducing kinase activity; K63-linked polyubiquitin modification-dependent protein binding; protein binding; ATP binding; ubiquitin protein ligase binding; protein kinase activity; protein phosphatase binding;
Cellular component	cytoplasm; cytosol; PML body; mitochondrial membranes; endosome membrane; nucleus; nucleoplasm;
Biological process	cellular response to virus; phosphorylation; I-kappaB phosphorylation; response to interferon-beta; cellular response to DNA damage stimulus; TRIF-dependent toll-like receptor signaling pathway; protein phosphorylation; response to type I interferon; immune response; intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of type I interferon production; protein homooligomerization; NIK/NF-kappaB signaling; positive regulation of lipid storage; peptidyl-serine phosphorylation; innate immune response; viral process; positive regulation of type I interferon-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9641
	56489
	ENSG00000263528
	ENSMUSG00000042349
	Q14164
	Q9R0T8
	NM_001193321; NM_001193322; NM_014002
	NM_019777
	NP_001180250; NP_001180251; NP_054721
	NP_062751
	Wikidata
View/Edit Human	View/Edit Mouse

Inhibitor of nuclear factor kappa-B kinase subunit epsilon also known as I-kappa-B kinase epsilon or IKK-epsilon is an enzyme that in humans is encoded by the IKBKE gene.