Interleukin 17F

IL17F
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JPY, 3JVF
Identifiers
Aliases	IL17F, CANDF6, IL-17F, ML-1, ML1, interleukin 17F, IL17A
External IDs	OMIM: 606496; MGI: 2676631; HomoloGene: 17115; GeneCards: IL17F; OMA:IL17F - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	52,244,500 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	20,860,841 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; bone marrow cells; ; appendix; ; tonsil; ; left testis; ; lymph node; ; right testis; ; duodenum; ; urinary bladder;
	Top expressed in
	zygote; ; secondary oocyte; ; embryo; ; embryo; ; Rostral migratory stream; ; blastocyst; ; primary oocyte; ; proximal tubule; ; tail of embryo; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; protein binding; protein homodimerization activity; cytokine binding; cytokine receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	negative regulation of angiogenesis; positive regulation of cytokine production involved in inflammatory response; cartilage development; positive regulation of transcription by RNA polymerase II; regulation of transforming growth factor beta receptor signaling pathway; inflammatory response; regulation of signaling receptor activity; cytokine-mediated signaling pathway; interleukin-17-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	112744
	257630
	ENSG00000112116
	ENSMUSG00000041872
	Q96PD4
	Q7TNI7
	NM_052872; NM_172343
	NM_145856
	NP_443104
	NP_665855
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 17F (IL-17F) is signaling protein that is in human which is encoded by the IL17F gene and is considered a pro-inflammatory cytokine. This protein belongs to the interleukin 17 family and is mainly produced by the T helper 17 cells after their stimulation with interleukin 23. However, IL-17F can be also produced by a wide range of cell types, including innate immune cells and epithelial cells.

The IL17F gene is located on chromosome 6p12 and was discovered in 2001. This cytokine can be secreted as disulfide-linked homodimer or heterodimer.