IL1RAP

IL1RAP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3O4O, 4DEP
Identifiers
Aliases	IL1RAP, C3orf13, IL-1RAcP, IL1R3, interleukin 1 receptor accessory protein
External IDs	OMIM: 602626; MGI: 104975; HomoloGene: 1643; GeneCards: IL1RAP; OMA:IL1RAP - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	190,659,750 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	26,548,867 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; placenta; ; blood; ; Achilles tendon; ; hair follicle; ; gingival epithelium; ; olfactory zone of nasal mucosa; ; gallbladder; ; germinal epithelium; ; monocyte;
	Top expressed in
	left lobe of liver; ; lumbar subsegment of spinal cord; ; medial geniculate nucleus; ; dentate gyrus of hippocampal formation granule cell; ; granulocyte; ; medial dorsal nucleus; ; primary oocyte; ; habenula; ; lateral geniculate nucleus; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interleukin-1 receptor activity; protein tyrosine kinase binding; interleukin-33 receptor activity; signal transducer activity; interleukin-1 receptor binding;
Cellular component	integral component of membrane; extracellular region; integral component of plasma membrane; membrane; plasma membrane; extracellular space; glutamatergic synapse;
Biological process	innate immune response; inflammatory response; immune response; signal transduction; cytokine-mediated signaling pathway; immune system process; positive regulation of NF-kappaB transcription factor activity; positive regulation of dendrite development; interleukin-33-mediated signaling pathway; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of synapse assembly; protein-containing complex assembly; interleukin-1-mediated signaling pathway; regulation of postsynaptic density assembly; trans-synaptic signaling by trans-synaptic complex; synaptic membrane adhesion; regulation of presynapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	3556
	16180
	ENSG00000196083
	ENSMUSG00000022514
	Q9NPH3
	Q61730
NM_001167928; NM_001167929; NM_001167930; NM_001167931; NM_002182;
	NM_134470; NM_001364879; NM_001364880; NM_001364881
	NM_001159317; NM_001159318; NM_008364; NM_134103
NP_001161400; NP_001161401; NP_001161402; NP_001161403; NP_002173;
	NP_608273; NP_001351808; NP_001351809; NP_001351810
	NP_001152789; NP_001152790; NP_032390; NP_598864
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene.

Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble.