IL1RL2

IL1RL2
Identifiers
Aliases	IL1RL2, IL-1Rrp2, IL-36R, IL1R-rp2, IL1RRP2, interleukin 1 receptor like 2
External IDs	OMIM: 604512; MGI: 1913107; HomoloGene: 2860; GeneCards: IL1RL2; OMA:IL1RL2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	102,240,002 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	40,406,722 bp
RNA expression pattern
	Top expressed in
	testicle; ; skin of abdomen; ; skin of leg; ; right lobe of thyroid gland; ; right lobe of liver; ; cartilage tissue; ; left lobe of thyroid gland; ; right uterine tube; ; minor salivary glands; ; mucosa of transverse colon;
	Top expressed in
	lip; ; conjunctival fornix; ; gastrula; ; skin of external ear; ; skin of back; ; seminal vesicula; ; esophagus; ; epidermis; ; hair follicle; ; lacrimal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interleukin-1, type I, activating receptor activity; interleukin-1 receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane;
Biological process	positive regulation of T cell differentiation; immune system process; interleukin-1-mediated signaling pathway; cellular defense response; innate immune response; inflammatory response; signal transduction; regulation of inflammatory response; positive regulation of interleukin-6 production; cytokine-mediated signaling pathway; cellular response to cytokine stimulus;
	Sources:Amigo / QuickGO
Orthologs
	8808
	107527
	ENSG00000115598
	ENSMUSG00000070942
	Q9HB29
	Q9ERS7
NM_003854; NM_001351446; NM_001351447; NM_001351448; NM_001351449;
	NM_001351450
	NM_133193; NM_001356478
NP_003845; NP_001338375; NP_001338376; NP_001338377; NP_001338378;
	NP_001338379
	NP_573456; NP_001343407
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene.

The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.