Interleukin-1 receptor antagonist

IL1RN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ILR, 1ILT, 1IRA, 1IRP, 2IRT
Identifiers
Aliases	IL1RN, DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4, interleukin 1 receptor antagonist
External IDs	OMIM: 147679; MGI: 96547; HomoloGene: 11163; GeneCards: IL1RN; OMA:IL1RN - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	113,134,016 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	24,241,506 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; palpebral conjunctiva; ; mucosa of pharynx; ; gums; ; oral cavity; ; gingival epithelium; ; body of tongue; ; periodontal fiber; ; amniotic fluid; ; skin of abdomen;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; lip; ; esophagus; ; lumbar subsegment of spinal cord; ; left colon; ; skin of back; ; skin of external ear; ; skin of abdomen; ; conjunctival fornix;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	interleukin-1 type I receptor antagonist activity; interleukin-1, type II receptor binding; protein binding; interleukin-1, type I receptor binding; interleukin-1 type II receptor antagonist activity; interleukin-1 receptor binding; cytokine activity; interleukin-1 receptor antagonist activity;
Cellular component	cytoplasm; vesicle; plasma membrane; intracellular anatomical structure; extracellular region; extracellular exosome; extracellular space;
Biological process	negative regulation of interleukin-1-mediated signaling pathway; lipid metabolism; response to glucocorticoid; insulin secretion; acute-phase response; negative regulation of heterotypic cell-cell adhesion; negative regulation of cytokine-mediated signaling pathway; inflammatory response; immune response; fever generation; regulation of signaling receptor activity; cytokine-mediated signaling pathway; neutrophil chemotaxis; positive regulation of interleukin-6 production; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of JNK cascade; interleukin-1-mediated signaling pathway; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	3557
	16181
	ENSG00000136689
	ENSMUSG00000026981
	P18510
	P25085
NM_000577; NM_173841; NM_173842; NM_173843; NM_001318914;
	NM_001379360
	NM_001039701; NM_001159562; NM_031167
NP_000568; NP_001305843; NP_776213; NP_776214; NP_776215;
	NP_001366289
	NP_001034790; NP_001153034; NP_112444
	Wikidata
View/Edit Human	View/Edit Mouse

The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene.

IL-1RA was initially called the IL-1 inhibitor and was discovered separately in 1984 by two independent laboratories. IL-1RA is an agent that binds non-productively to the cell surface interleukin-1 receptor (IL-1R), the same receptor that binds interleukin 1 family (IL-1), preventing IL-1's from sending a signal to that cell.