Interleukin 20 receptor, beta subunit

IL20RB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DOH
Identifiers
Aliases	IL20RB, DIRS1, FNDC6, IL-20R2, Interleukin 20 receptor, beta subunit, interleukin 20 receptor subunit beta
External IDs	OMIM: 605621; MGI: 2143266; HomoloGene: 86034; GeneCards: IL20RB; OMA:IL20RB - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	137,011,085 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	100,368,841 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; skin of abdomen; ; skin of thigh; ; human penis; ; skin of hip; ; gingival epithelium; ; vulva; ; mucosa of pharynx; ; nipple; ; oral cavity;
	Top expressed in
	lip; ; skin of external ear; ; esophagus; ; cerebellar cortex; ; skin of back; ; skin of abdomen; ; morula; ; lobe of cerebellum; ; cerebellar vermis; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	interleukin-20 binding; interleukin-10 receptor activity; protein binding; cytokine receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	homeostasis of number of cells within a tissue; immune response-inhibiting signal transduction; negative regulation of T cell proliferation; negative regulation of interferon-gamma production; negative regulation of interleukin-2 production; negative regulation of type IV hypersensitivity; positive regulation of interleukin-4 production; inflammatory response to antigenic stimulus; regulation of T cell activation; positive regulation of interleukin-10 production; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	53833
	213208
	ENSG00000174564
	ENSMUSG00000044244
	Q6UXL0
	E9Q9A6
	NM_144717
	NM_001033543; NM_001037246
	NP_653318
	NP_001028715
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 20 receptor, beta subunit (IL20R2 or IL20RB) is a subunit of the interleukin-20 receptor and interleukin-22 receptor. It is believed to be involved in both pro-inflammatory and anti-inflammatory responses.

IL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis, osteoclasts, found in bones, and epithelial cells of the intestine and trachea. IL20RB is also found in some immune cells. The subunit has been linked with multiple diseases, including gastrointestinal diseases and glaucoma.