Integrin-linked kinase

ILK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HI9, 2KBX, 3F6Q, 3IXE, 3KMU, 3KMW, 3REP, 4HI8
Identifiers
Aliases	ILK, HEL-S-28, ILK-1, ILK-2, P59, p59integrin linked kinase
External IDs	OMIM: 602366; MGI: 1195267; HomoloGene: 3318; GeneCards: ILK; OMA:ILK - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	6,610,874 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	105,392,132 bp
RNA expression pattern
	Top expressed in
	body of uterus; ; popliteal artery; ; tibial arteries; ; right coronary artery; ; muscle layer of sigmoid colon; ; thoracic aorta; ; ascending aorta; ; Descending thoracic aorta; ; saphenous vein; ; left coronary artery;
	Top expressed in
	uterus; ; granulocyte; ; umbilical cord; ; ascending aorta; ; optic nerve; ; tunica media of zone of aorta; ; genital tubercle; ; tail of embryo; ; cervix; ; efferent ductule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; SH3 domain binding; kinase activity; integrin binding; protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase binding; signal transducer activity;
Cellular component	cell projection; membrane; cell-cell junction; plasma membrane; sarcomere; nucleoplasm; dendritic shaft; cell junction; soma; terminal bouton; axon; costamere; lamellipodium; stress fiber; cytoplasm; cytosol; focal adhesion;
Biological process	fibroblast migration; negative regulation of neuron apoptotic process; negative regulation of smooth muscle cell proliferation; neuron projection morphogenesis; positive regulation of protein kinase B signaling; regulation of actin cytoskeleton organization; positive regulation of MAP kinase activity; protein kinase B signaling; protein heterooligomerization; negative regulation of protein kinase activity; phosphorylation; myelin assembly; positive regulation of cell-matrix adhesion; positive regulation of cell migration; positive regulation of canonical Wnt signaling pathway; Schwann cell development; negative regulation of neural precursor cell proliferation; outflow tract morphogenesis; negative regulation of smooth muscle cell migration; negative regulation of apoptotic process; myelination in peripheral nervous system; positive regulation of axonogenesis; positive regulation of transcription, DNA-templated; protein phosphorylation; negative regulation of cardiac muscle cell apoptotic process; branching involved in ureteric bud morphogenesis; positive regulation of osteoblast differentiation; positive regulation of dendrite morphogenesis; cell projection organization; positive regulation of myoblast differentiation; peptidyl-serine phosphorylation; establishment or maintenance of epithelial cell apical/basal polarity; regulation of cell growth; positive regulation of cell population proliferation; positive regulation of BMP signaling pathway; integrin-mediated signaling pathway; substrate adhesion-dependent cell spreading; positive regulation of phosphorylation; cell-matrix adhesion; cell population proliferation; positive regulation of axon extension; platelet aggregation; nerve development; positive regulation of MAPK cascade; cell junction assembly; MAPK cascade; multicellular organism development; supramolecular fiber organization; tumor necrosis factor-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	3611
	16202
	ENSG00000166333
	ENSMUSG00000030890
	Q13418
	O55222
	NM_001014794; NM_001014795; NM_001278441; NM_001278442; NM_004517
	NM_001161724; NM_010562
	NP_001014794; NP_001014795; NP_001265370; NP_001265371; NP_004508
	NP_001155196; NP_034692
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction. Mutations in ILK are associated with cardiomyopathies. It is a 59kDa protein originally identified in a yeast-two hybrid screen with integrin β1 as the bait protein. Since its discovery, ILK has been associated with multiple cellular functions including cell migration, proliferation, and adhesion.

Integrin-linked kinases (ILKs) are a subfamily of Raf-like kinases (RAF). The structure of ILK consists of three features: 5 ankyrin repeats in the N-terminus, Phosphoinositide binding motif and extreme N-terminus of kinase catalytic domain. Integrins lack enzymatic activity and depend on adapters to signal proteins. ILK is linked to beta-1 and beta-3 integrin cytoplasmic domains and is one of the best described integrins. Although first described as a serine/threonine kinase by Hannigan, important motifs of ILK kinases are still uncharacterized. ILK is thought to have a role in development regulation and tissue homeostasis, however it was found that in flies, worms and mice ILK activity isn't required to regulate these processes.

Animal ILKs have been linked to the pinch- parvin complex which control muscle development. Mice lacking ILK were embryonic lethal due to lack of organized muscle cell development. In mammals ILK lacks catalytic activity but supports scaffolding protein functions for focal adhesions. In plants, ILKs signal complexes to focal adhesion sites. ILKs of plants contain multiple ILK genes. Unlike animals that contain few ILK genes ILKs have been found to possess oncogenic properties. ILKs control the activity of serine/threonine phosphatases.