IMMT

IMMT
Identifiers
Aliases	IMMT, HMP, MINOS2, P87, P87/89, P89, PIG52, Mic60, PIG4, inner membrane mitochondrial protein, MICOS60, mitofilin
External IDs	OMIM: 600378; MGI: 1923864; HomoloGene: 38234; GeneCards: IMMT; OMA:IMMT - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	86,195,472 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	71,854,372 bp
RNA expression pattern
	Top expressed in
	left ventricle; ; gastrocnemius muscle; ; apex of heart; ; right auricle of heart; ; biceps brachii; ; right ventricle; ; Skeletal muscle tissue of biceps brachii; ; gonad; ; right adrenal cortex; ; body of tongue;
	Top expressed in
	myocardium of ventricle; ; tail of embryo; ; genital tubercle; ; right kidney; ; right ventricle; ; cardiac muscles; ; soleus muscle; ; muscle of thigh; ; digastric muscle; ; brown adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	integral component of membrane; mitochondrial inner membrane; myelin sheath; MICOS complex; membrane; mitochondrion;
Biological process	cristae formation; mitochondrial calcium ion homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	10989
	76614
	ENSG00000132305
	ENSMUSG00000052337
	Q16891
	Q8CAQ8
	NM_001100169; NM_001100170; NM_006839
NM_001253681; NM_001253686; NM_001253687; NM_001253688; NM_001253689;
	NM_029673; NM_001362134; NM_001362136; NM_001362137; NM_001362138
	NP_001093639; NP_001093640; NP_006830
NP_001240610; NP_001240615; NP_001240616; NP_001240617; NP_001240618;
	NP_083949; NP_001349063; NP_001349065; NP_001349066; NP_001349067
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial inner membrane protein is a protein that in humans is encoded by the IMMT gene.)

IMMT encodes an inner mitochondrial membrane (IMM) protein in the nucleus. It is posttranslational transported to the IMM. Mic60/Mitofilin (encoded by the IMMT gene) is a core subunit of the MICOS-complex, directly located next to cristae junctions (CJ). Human Mic60 exists in two isoforms of different size, anchored to the IMM via its N-terminus, while most of the protein is located to the inner mitochondrial space (IMS).